Certificate of Analysis
| Product Name: | AMG-548 dihydrochloride |
| Catalog Number: | M45284 |
| CAS Number: | 2518299-32-4 |
Physical and Chemical Properties
| Formula: | C29H29Cl2N5O |
| Molecular Weight: | 534.48 |
| Form: | Solid |
| Solubility: | DMSO 10 mg/mL |
| Storage: | -20°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |