Certificate of Analysis
| Product Name: | AMG 548 |
| Catalog Number: | M6434 |
| CAS Number: | 864249-60-5 |
Physical and Chemical Properties
| Formula: | C29H27N5O |
| Molecular Weight: | 461.56 |
| Solubility: | DMSO 49.8 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >98% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | AMG 548 is an orally potent and selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ. In addition, AMG 548 also potently inhibited whole blood LPS-stimulated TNFα (IC50=3 nM) and inhibited Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |