Certificate of Analysis
| Product Name: | Agomelatine |
| Catalog Number: | M2230 |
| CAS Number: | 138112-76-2 |
Physical and Chemical Properties
| Formula: | C15H17NO2 |
| Molecular Weight: | 243.3 |
| Solubility: | DMSO 60 mg/mL; Ethanol 20 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.93% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. Agomelatine is also a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |