Certificate of Analysis
| Product Name: | Adaptaquin |
| Catalog Number: | M6406 |
| CAS Number: | 385786-48-1 |
Physical and Chemical Properties
| Formula: | C21H16ClN3O2 |
| Molecular Weight: | 377.82 |
| Solubility: | DMSO 37.78 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Adaptaquin is a hIF-prolyl hydroxylase-2 (PHD2) inhibitor. Adaptaquin blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Adaptaquin exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |