Certificate of Analysis
| Product Name: | 4-Hydroxyestradiol |
| Catalog Number: | M59004 |
| CAS Number: | 5976-61-4 |
Physical and Chemical Properties
| Formula: | C18H24O3 |
| Molecular Weight: | 288.38 |
| Form: | Solid |
| Solubility: | DMSO 20 mg/mL |
| Storage: | -20°C, dry |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | 4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM. 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |