Certificate of Analysis

 

Catalog Number: M5346
Product Name: WZ3146
CAS Number: 1214265-56-1

Physical and Chemical Properties
Formula: C24H25ClN6O2
Molecular Weight: 464.95
Solubility: 93 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: WZ3146 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.