Certificate of Analysis
| Product Name: | Vimirogant hydrochloride |
| Catalog Number: | M31061 |
| CAS Number: | 1802678-42-7 |
Physical and Chemical Properties
| Formula: | C27H35F3N4O3S.xHCl |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL (ultrasonic); Ethanol 50 mg/mL (ultrasonic) |
| Storage: | 4°C, dry, sealed |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |