Certificate of Analysis

 

Product Name: TP0427736 HCl
Catalog Number: M20633
CAS Number: 864374-00-5

Physical and Chemical Properties
Formula: C14H11ClN4S2
Molecular Weight: 334.85
Solubility: DMSO 67 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: TP0427736 HCl Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.