Certificate of Analysis


Catalog Number: M1827
Product Name: Sorafenib Tosylate
CAS Number: 475207-59-1

Physical and Chemical Properties
Formula: C21H16ClF3N4O3.C7H8O3S
Molecular Weight: 637.03
Solubility: DMSO ≥100 mg/mL
Long-term Storage: at -20°C
Chemical Structure: Sorafenib Tosylate Structure
Analytical Data
HPLC: Shows Min 99.98% purity
H-NMR: Consistent with structure
Product Information
Description: Sorafenib (BAY 43-9006) is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.