Certificate of Analysis
| Product Name: | SI-109 |
| Catalog Number: | M21406 |
| CAS Number: | 2429877-30-3 |
Physical and Chemical Properties
| Formula: | C40H44F2N7O9P |
| Molecular Weight: | 835.8 |
| Solubility: | DMSO ≥ 100 mg/mL |
| Storage: | -20°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ＞99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | SI-109 is a potent STAT3 SH2 domain structural domain inhibitor (Ki=9 nM) with antitumor activity. si-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). si-109 and the CRBN analogue lenalidomide ligand were used to design the PROTAC STAT3 degradation agent SD- 36. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |