Certificate of Analysis
| Catalog Number: | M2277 |
| Product Name: | Semagacestat |
| CAS Number: | 425386-60-3 |
Physical and Chemical Properties
| Formula: | C19H27N3O4 |
| Molecular Weight: | 361.44 |
| Solubility: | DMSO 50 mg/mL |
| Long-term Storage: | at -20°C |
| Chemical Structure: |  |
Analytical Data
| HPLC: | Shows Min >99% purity |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. |