Certificate of Analysis

 

Catalog Number: M2277
Product Name: Semagacestat
CAS Number: 425386-60-3

Physical and Chemical Properties
Formula: C19H27N3O4
Molecular Weight: 361.44
Solubility: DMSO 50 mg/mL
Long-term Storage: at -20℃
Chemical Structure: Semagacestat Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.