Certificate of Analysis
| Product Name: | Adezmapimod (SB203580) |
| Catalog Number: | M1781 |
| CAS Number: | 152121-47-6 |
Physical and Chemical Properties
| Formula: | C21H16FN3OS |
| Molecular Weight: | 377.43 |
| Solubility: | DMSO 20 mg/mL (ultrasonic and warming) |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.97% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |