Certificate of Analysis

 

Product Name: PFI-2
Catalog Number: M5128
CAS Number: 1627676-59-8

Physical and Chemical Properties
Formula: C23H25F4N3O3S
Molecular Weight: 499.52
Solubility: DMSO 99 mg/mL; Water 4 mg/mL warmed
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: PFI-2 Structure
Analytical Data
QC Standard: >98%
H-NMR: Consistent with structure
Product Information
Description: PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.