|Solubility:||DMSO 80 mg/mL, Water 80 mg/mL|
|Long-term Storage:||at -20°C|
|HPLC:||Shows Min >98% purity|
|H-NMR:||Consistent with structure|
|Description:||PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively.|
|Stability and Solubility Advice:|| Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.