Certificate of Analysis

 

Catalog Number: M2447
Product Name: PF-5274857
CAS Number: 1373615-35-0

Physical and Chemical Properties
Formula: C20H25ClN4O3S
Molecular Weight: 436.96
Solubility: DMSO 80 mg/mL, Water 80 mg/mL
Long-term Storage: at -20℃
Chemical Structure: PF-5274857 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.