Certificate of Analysis

 

Product Name: Pemetrexed disodium heptahydrate
Catalog Number: M29977
CAS Number: 357166-29-1

Physical and Chemical Properties
Formula: C20H21N5O6.7H2O.2Na
Molecular Weight: 599.5
Form: Solid
Solubility: Water 100 mg/mL (ultrasonic)
Storage: 4°C, dry, sealed
Chemical Structure: Pemetrexed disodium heptahydrate Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.