Certificate of Analysis

 
Product Name: Pazopanib HCl (GW786034)
Catalog Number: M5863
CAS Number: 635702-64-6
Physical and Chemical Properties
Formula: C21H23N7O2S.HCl
Molecular Weight: 473.98
Solubility: DMSO 10 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Pazopanib HCl (GW786034) Structure
Analytical Data
QC Standard: 99.89%
H-NMR: Consistent with structure
Product Information
Description: Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.