Certificate of Analysis

 

Catalog Number: M5270
Product Name: NMS-P118
CAS Number: 1262417-51-5

Physical and Chemical Properties
Formula: C20H24F3N3O2
Molecular Weight: 395.42
Solubility: 24 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: NMS-P118 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.