Certificate of Analysis


Catalog Number: M1920
Product Name: Motesanib Diphosphate
CAS Number: 857876-30-3

Physical and Chemical Properties
Formula: C22H23N5O.2H3PO4
Molecular Weight: 569.44
Solubility: DMSO 100 mg/mL, Water 100 mg/mL
Long-term Storage: at -20°C
Chemical Structure: Motesanib Diphosphate Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: Motesanib (AMG 706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM, 3 nM, 6 nM, 84 nM, 8 nM and 59 nM, respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.