Certificate of Analysis

 

Catalog Number: M3515
Product Name: MK-2461
CAS Number: 917879-39-1

Physical and Chemical Properties
Formula: C24H25N5O5S
Molecular Weight: 495.55
Solubility: DMSO 90 mg/mL
Long-term Storage: at -20℃
Chemical Structure: MK-2461 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.