Certificate of Analysis


Catalog Number: M6151
Product Name: LOXO-101
CAS Number: 1223403-58-4

Physical and Chemical Properties
Formula: C21H22F2N6O2
Molecular Weight: 428.44
Solubility: 4.6 mg/mL in DMSO
Long-term Storage: at -20°C
Chemical Structure: LOXO-101 Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: LOXO-101 is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.