Certificate of Analysis

 

Product Name: Lonafarnib
Catalog Number: M2307
CAS Number: 193275-84-2

Physical and Chemical Properties
Formula: C27H31Br2ClN4O2
Molecular Weight: 638.82
Solubility: DMSO 50 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Lonafarnib Structure
Analytical Data
QC Standard: 100.00%
H-NMR: Consistent with structure
Product Information
Description: Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.