Certificate of Analysis

 

Catalog Number: M3269
Product Name: KRN 633
CAS Number: 286370-15-8

Physical and Chemical Properties
Formula: C20H21ClN4O4
Molecular Weight: 416.86
Solubility: DMSO
Long-term Storage: at -20℃
Chemical Structure: KRN 633 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.