Certificate of Analysis

 

Product Name: GW806742X
Catalog Number: M8758
CAS Number: 579515-63-2

Physical and Chemical Properties
Formula: C25H22F3N7O4S
Molecular Weight: 573.55
Solubility: DMSO: ≥ 30 mg/mL
Storage: 4°C, dry, sealed
Chemical Structure: GW806742X Structure
Analytical Data
QC Standard: >98%
H-NMR: Consistent with structure
Product Information
Description: GW806742X is an ATP site-targeing kinase inhibitor (IC50 in nM = 2/VEGFR2, 15/SRC, 47/C-FMS, 851/GSK3, 9016/ERBB2, 9120/FGFR) with potent antiproliferation activity against cancer cultures (IC50 in nM = 5/HUVEC-v, 424/HUVEC-b, 81/HEF, 453/MDA468, 470/A375P, 693/HT29, 734/PC3), GW806742X is now better known as Compound 1 for its anti-necroptosis activity via affinity interaction with ML
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.