Certificate of Analysis
| Product Name: | GNE-1858 |
| Catalog Number: | M9766 |
| CAS Number: | 2680616-96-8 |
Physical and Chemical Properties
| Formula: | C21H26F2N8 |
| Molecular Weight: | 428.48 |
| Solubility: | DMSO ≥ 10 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | GNE-1858 is a highly potent ATP competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor that mimics the mutant strains HPK1-TSEE and HPK1-SA for wild-type and active strains IC50The s-values are 1.9 nM, 1.9 nM, and 4.5 nM, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |