Certificate of Analysis


Catalog Number: M1713
Product Name: GDC-0449
CAS Number: 879085-55-9

Physical and Chemical Properties
Formula: C19H14Cl2N2O3S
Molecular Weight: 421.3
Solubility: DMSO
Long-term Storage: at -20°C
Chemical Structure: GDC-0449 Structure
Analytical Data
HPLC: Shows Min 99.49% purity
H-NMR: Consistent with structure
Product Information
Description: GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.