Certificate of Analysis
| Product Name: | GDC-0449 (Vismodegib) |
| Catalog Number: | M1713 |
| CAS Number: | 879085-55-9 |
Physical and Chemical Properties
| Formula: | C19H14Cl2N2O3S |
| Molecular Weight: | 421.3 |
| Solubility: | DMSO 50 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.81% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |