Certificate of Analysis

 

Catalog Number: M3483
Product Name: Flavopiridol hydrochloride
CAS Number: 131740-09-5

Physical and Chemical Properties
Formula: C21H20ClNO5.HCl
Molecular Weight: 438.3
Solubility: DMSO 80 mg/mL
Long-term Storage: at -20℃
Chemical Structure: Flavopiridol hydrochloride Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.