Certificate of Analysis

 

Catalog Number: M8937
Product Name: CPI-455 HCl
CAS Number: 1628208-23-0 (free base)

Physical and Chemical Properties
Formula: C16H14N4O.HCl
Molecular Weight: 314.77
Solubility: DMSO: 10 mg/mL
Long-term Storage: at -20°C
Chemical Structure: CPI-455 HCl Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: CPI-455 HCl is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.