Certificate of Analysis
| Product Name: | Casimersen |
| Catalog Number: | M21455 |
| CAS Number: | 1422958-19-7 |
Physical and Chemical Properties
| Molecular Weight: | 7584.00 |
| Solubility: | Water ≥ 60 mg/mL |
| Storage: | -20°C, dry, sealed |
Analytical Data
| QC Standard: | ＞91% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Casimersen (SRP-4045) is an antisense oligonucleotide of the subclass of phosphodiamide morphorph oligomers. Casimersen binds to exon 45 of dystrophin's precursor mRNA to restore the open reading frame (by skipping exon 45), resulting in an internally truncated but functional dystrophin. Casimersen can be used in the study of Duchenne muscular dystrophy (DMD). |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |