Certificate of Analysis


Catalog Number: M5317
Product Name: Brigatinib
CAS Number: 1197953-54-0

Physical and Chemical Properties
Formula: C29H39ClN7O2P
Molecular Weight: 584.09
Solubility: 43 mg/mL warmed in DMSO
Storage: at -20°C
Chemical Structure: Brigatinib Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.