Certificate of Analysis

 

Catalog Number: M6202
Product Name: BLU-285
CAS Number: 1703793-34-3

Physical and Chemical Properties
Formula: C26H27FN10
Molecular Weight: 498.56
Solubility: 66 mg/mL in DMSO
Long-term Storage: at -20°C
Chemical Structure: BLU-285 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM).
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.