Certificate of Analysis

 

Product Name: AZD3759 (Zorifertinib)
Catalog Number: M5164
CAS Number: 1626387-80-1

Physical and Chemical Properties
Formula: C22H23ClFN5O3
Molecular Weight: 459.9
Solubility: DMSO 90 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: AZD3759 (Zorifertinib) Structure
Analytical Data
QC Standard: 98.63%
H-NMR: Consistent with structure
Product Information
Description: AZD3759 (Zorifertinib) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.