Certificate of Analysis

 

Catalog Number: M5164
Product Name: AZD3759
CAS Number: 1626387-80-1

Physical and Chemical Properties
Formula: C22H23ClFN5O3
Molecular Weight: 459.9
Solubility: DMSO 90 mg/mL
Long-term Storage: at -20℃
Chemical Structure: AZD3759 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: AZD3759 is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.