Certificate of Analysis
| Product Name: | Tivozanib (AV-951) |
| Catalog Number: | M1656 |
| CAS Number: | 475108-18-0 |
Physical and Chemical Properties
| Formula: | C22H19ClN4O5 |
| Molecular Weight: | 454.86 |
| Solubility: | DMSO 18 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 98.28% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | AV-951 (Tivozanib) is a potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |