About 28 results found for searched term "ML SA1" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6983 | ML SA1 | TRP Channel |
| ML SA1 is a activator of TRPML channels. | ||
| M15032 | Recombinant Human FGF-9 (E. coli) | Recombinant Proteins |
| Fibroblast Growth Factor-9; FGF9 | ||
| Fibroblast Growth Factor-9 (FGF-9) is a heparin binding growth factor that belongs to the fibroblast growth factor (FGF) family. ED50 < 2.0 ng/ mL, determined by 3T3 cell proliferation assay, corresponding to > 5.0× 105 units/mg. | ||
| M7627 | BIO | GSK-3 |
| 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime6BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052 | ||
| BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific GSK-3 inhibitor, the IC50 acting on GSK-3α/β in cell-free assays is 5 nM, which is more than 16 times more selective than ACTing on CDK5. It is also a pan-JAK inhibitor with an IC50 value of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. | ||
| M9842 | ML228 | HIF |
| CID-46742353; ML 228 | ||
| ML228 is a potent the HIF pathway activator, with EC50 values of 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively. | ||
| M10022 | Recombinant Mouse GM-CSF Protein (CHO) | Recombinant Proteins |
| CSF-2 | ||
| Recombinant GM-CSF Protein is a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. GM-CSF is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. ED50 < 0.05 ng/ml, measured in a cell proliferation assay using mouse FDC-P1 cells, corresponding to a specific activity of > 2.0 × 107 units/mg. | ||
| M10595 | MLi-2 | LRRK2 |
| MLi2 | ||
| MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). | ||
| M11485 | Recombinant Mouse GM-CSF Protein (E. coli) | Recombinant Proteins |
| Granulocyte Macrophage Colony Stimulating Factor; CSF-2; MGI-1GM | ||
| Expression system: E. coli Bioactivity: ED50 < 5.0 pg/ mL, measured in cell proliferation assay of mouse FDC-P1 cells, corresponding specific activity > 2.0 × 108 units/mg. | ||
| M11495 | Recombinant Human TNF-α (E. coli) | Recombinant Proteins |
| TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin | ||
| Recombinant human TNF-α protein (E. coli) is a homotrimer with a subunit molecular mass of 17.3 kDa. TNF-a plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases; and in viral, bacterial, fungal, and parasitic infections. ED50 < 30.0 pg/ml, measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of > 3.3 × 107 units/mg. | ||
| M15039 | Recombinant Rat Leptin (E. coli) | Recombinant Proteins |
| Obesity protein; OB; LEP; LEPD; OBS; leptin | ||
| Leptin is a cytokine belonging to the Interleukin 6 family, and has a four-helix bundle structure. Leptin also has effects on reproduction and immunity. ED50 < 10.0 µg/ml, measured by a cell proliferation assay using LoVo cells, corresponding to a specific activity of > 100.0 units/mg. | ||
| M16158 | Koenimbine | Alkaloids |
| NSC 127152; Koenimbin; Kenimbine | ||
| Koenimbine is a natural product isolated from Murraya koenigii. The IC50 values of koenimbine in HT-29 and SW48 was calculated to be 50 μg/ml based on the MTT assay. The IC50 value was 75 μg/ml in IEC-18 cells. | ||
| M20003 | Recombinant Human IFN alpha2a (E.coli) | Recombinant Proteins |
| Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A | ||
| Recombinant human interferon Alpha-2a was produced by an E. coli expression system. Protein No. P01563. ED50 < 0.1 ng/ml, measured by cytotoxicity assay using TF-1 cells, corresponding to specific activity > 1.0 × 107 units/mg. | ||
| M21057 | Recombinant Human TNF-β (E. coli) | Recombinant Proteins |
| LTA; LT; TNFB; TNFSF1 | ||
| ED50 < 4.0 pg/ml, measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of > 2.5 × 108 units/mg. | ||
| M21096 | TXA6101 | Others |
| TXA6101 is a filamentous temperature-sensitive mutant Z (FtsZ) protein inhibitor. TXA6101 has an antibacterial activity MIC value of 1 μg/mL against MRSA isolates expressing either G193D or G196S mutant FtsZ, retaining significant activity against the TXA707-resistant FtsZ mutant. It is being developed for use against Gram-negative bacteria. | ||
| M21210 | Recombinant Mouse IL-3 (E. coli) | Recombinant Proteins |
| IL3; interleukin 3; IL-3; MCGF | ||
| ED50 < 0.05 ng/ml, measured by cell proliferation assay using M-NFS-60 cells, corresponds to specific activity > 2.0 × 10 7 units/mg. Accession # P01586. | ||
| M21438 | Recombinant Mouse CXCL1/GRO-α/KC (CHO) | Recombinant Proteins |
| Mouse CXCL1/GRO-α is a potent neutrophil attractant and activator. CXCL1 was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease. Active at 10.0 ng/ml, measured in a tube formation assay using HUVEC cells. Accession # P12850 | ||
| M21621 | Recombinant Rat GM-CSF Protein (CHO) | Recombinant Proteins |
| Granulocyte Macrophage-Colony Stimulating Factor | ||
| Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. ED50 < 5.0 pg/ml, measured in a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 2.0 × 108 units/mg. | ||
| M21678 | Recombinant Human IL-9 Protein (CHO) | Recombinant Proteins |
| interleukin-9 | ||
| Recombinant Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. ED50 < 1.0 ng/ml, measured in a cell proliferation assay using MO7e cells, corresponding to a specific activity of > 1.0 × 106 units/mg. | ||
| M21721 | Recombinant Mouse IGF-I Protein (E. coli) | Recombinant Proteins |
| Insulin-like Growth Factor I | ||
| Recombinant Mouse IGF-I belongs to the IGF family of peptides, which also includes IGF-II and insulin. IGF-I executes its functions via signaling through transmembrane tyrosine receptors (IGF Receptors). ED50 < 10.0 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | ||
| M25152 | Bamlanivimab | Anti-infection |
| Anti-Human SARS-CoV-2 | ||
| Bamlanivimab (Anti-Human SARS-CoV-2) is the first COVID-19 monoclonal antibody (mAb) to be granted Emergency Use Authorization (EUA) in November 2020 by the U.S. Food and Drug Administration (FDA). However, Bamlanivimab is withdrawn in April 2021 following the rise of SARS-CoV-2 virus variants resistant to Bamlanivimab. | ||
| M25396 | Recombinant Human Oncostatin M (OSM) (E. coli, 209aa) | Recombinant Proteins |
| OSM | ||
| Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | ||
| M25397 | Recombinant Human Oncostatin M (OSM) (E. coli, 227aa) | Recombinant Proteins |
| OSM | ||
| Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, including IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | ||
| M25418 | Recombinant Mouse IL-1β (CHO) | Recombinant Proteins |
| interleukin 1 beta | ||
| Interleukin-1 Beta (IL-1β) (E. coli) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. ED50 < 10.0 pg/ml, measured in a cell proliferation assay using D10S cells, corresponding to a specific activity of > 1.0 × 108 units/mg. | ||
| M28651 | ML401 | GPR/FFAR |
| ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity. | ||
| M29135 | SAHM1 | Notch |
| SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice. | ||
| M29630 | ML-SA5 | TRP Channel |
| ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth. | ||
| M30828 | BMS-688521 | Integrin |
| BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC50 of 2.5 nM in the adhesion assay and an IC50 of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model. | ||
| M43924 | MLT-943 | MALT1 |
| MLT-943 is a potent, selective, and orally active inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1) that inhibits IL-2 secretion in PBMC or whole blood with IC50 values of 0.07-0.09 μM and 0.6-0.8 μM, respectively.In addition, MLT-943 possesses anti-inflammatory activity and can be used in studies of FcgR-mediated inflammation . | ||
| M45102 | ML188 | Anti-infection |
| ML188 is a first-in-class probe and also a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. antiviral activity. | ||
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