About 19 results found for searched term "Histone Acetyltransferase" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4898 | Histone Acetyltransferase Inhibitor II | Histone Acetyltransferase |
| Histone Acetyltransferase Inhibitor II, insulin producing cells capable of secreting blood glucose regulating hormones, specially insulin, in response to physiological signals, method of production of said cells and uses thereof. | ||
| M2198 | Curcumin | Histone Acetyltransferase |
| Indian Saffron; Turmeric yellow; Natural Yellow 3; Diferuloylmethane | ||
| Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. | ||
| M2482 | C646 | Histone Acetyltransferase |
| C 646 | ||
| C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases. | ||
| M7738 | CPTH2 | Histone Acetyltransferase |
| CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. | ||
| M8245 | SPV-106 | Others |
| SPV106 is a mixed inhibitor/activator of histone acetyltransferase (HAT) activity. | ||
| M8467 | OF-1 | Others |
| OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. | ||
| M9445 | YF2 | Histone Acetyltransferase |
| YF-2 | ||
| YF2 is a selective HAT (histone acetyltransferase) activator, with EC50 values of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF and GCN5, respectively. | ||
| M9919 | TH1834 | Histone Acetyltransferase |
| TH-1834 | ||
| TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. | ||
| M11348 | Garcinol | AChR/AChE |
| Garcinol is a kind of polyisoprene diphenylketone extracted from Garcinia japonicum. It has anticholinesterase properties for AChE and butyrylcholinesterase (BChE) with IC50 of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibited histone acetyltransferases (HATs, IC50=7 μM) and P300 /CPB related factors (PCAF, IC50=5 μM). Garcinol has anti-inflammatory and anticancer activities. | ||
| M13827 | Butyrolactone 3 | Histone Acetyltransferase |
| MB-3 | ||
| Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. | ||
| M21260 | CPI-1612 | Histone Acetyltransferase |
| CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species. | ||
| M25561 | CTB | Histone Acetyltransferase |
| CTB is a potent p300 histone acetyltransferase activator. CTB induces time dependence apoptosis of MCF-7 cells. | ||
| M25562 | TTK21 | Histone Acetyltransferase |
| TTK-21 | ||
| TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has potential for research of brain neurogenesis and long-term memory function. | ||
| M28625 | PU139 | Histone Acetyltransferase |
| PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively. | ||
| M29245 | TH1834 dihydrochloride | Histone Acetyltransferase |
| TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity. | ||
| M29580 | SYY-B085-1 | Histone Acetyltransferase |
| SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor extracted from patent WO2019201291A1. | ||
| M45100 | KDM2A/7A-IN-1 | Histone demethylase |
| KDM2A/7A-IN-1 is a first-in-class, selective, cell-permeable inhibitor of the histone lysine demethylase KDM2A/7A, with an IC50 value of 0.16 μM for KDM2A, 75-fold more selective than other JmjC lysine demethylases, and with no effect on methyltransferases or histone acetyltransferases. KDM2A was 75 times more selective than other JmjC lysine demethylases and had no effect on methyltransferases and histone acetyltransferases. | ||
| M50943 | Histone H3 (5-23) | Others |
| Histone H3 (5-23), derived from histone H3 5-23 amino acids, can be used as a substrate for histone acetyltransferase (HAT) assays. | ||
| M54488 | Histone H3 (1-21) | Others |
| Histone H3 (1-21), derived from Histone H3 1-21 amino acids, is usually used as a substrate for methyltransferase (Histone 3 K4 and K9) and acetyltransferase (Histone 3 K9 and K14) assays. | ||
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