Testosterone Propionate is a potent anabolic steroid used in the study of low testosterone level disorders, where it is an agonist of the androgen receptor (AR). In addition, Testosterone Propionate is also used in the construction of animal disease models (e.g. rat prostate hyperplasia model, rat seborrheic alopecia rat model, etc.).
Benign Prostate Hyperplasia, BPH
Seven-week-old male SD rats were castrated to exclude intrinsic testosterone and received a subcutaneous injection of 3 mg/kg testosterone propionate (TP) to induce BPH.
J Ovarian Res. 2023 Jan 14;16(1):10.
Androgen increases klotho expression via the androgen receptor-mediated pathway to induce GCs apoptosis
Testosterone propionate purchased from AbMole
| Molecular Weight | 344.49 |
| Formula | C22H32O3 |
| CAS Number | 57-85-2 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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