Tenuifolin
 |
Source | Bioanalysis (2014). Figure 5. Tenuifolin |
| Method | i.g. | |
| Cell Lines | Kunming mice | |
| Concentrations | 200mg/kg | |
| Incubation Time | 30 min | |
| Results | As shown in Figure 5, when compared to control, 200mg/kg of OJB, TEN, and SNG had no significant effect on TNF-а level (p > 0.05). |
 |
Source | Bioanalysis (2014). Figure 4. Tenuifolin |
| Method | i.g. | |
| Cell Lines | Kunming mice | |
| Concentrations | 200mg/kg | |
| Incubation Time | 30 min | |
| Results | As shown in Figure 4, when compared to control, 200 mg/kg of OJB, TEN, or SNG could significantly reduce the gastric PGE2 level (p < 0.05), and the effects of OJB were greater than that of TEN (p< 0.05). |
| Cell Experiment | |
|---|---|
| Cell lines | PC12 cells |
| Preparation method | The cells were inoculated into poly-L-lysine-coated 96-well culture plates at 5 × 103 cells/well and treated with different concentrations of tenuifolin and fallaxsaponin for 24 h and subsequently co-cultured with 25 μM prepared Aβ25–35 peptide for an additional 24 h. |
| Concentrations | 10, 20 and 40 μg/L |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | dysmnesia mice |
| Formulation | distilled water |
| Dosages | 0.02, 0.04, 0.08 g/kg |
| Administration | oral |
| Molecular Weight | 680.82 |
| Formula | C36H56O12 |
| CAS Number | 20183-47-5 |
| Solubility (25°C) | Methanol |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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