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Cat. No. M4188
Tenuifolin Structure
Size Price Availability Quantity
20mg USD 378  USD420 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity


Customer Product Validations & Biological Datas
Source Bioanalysis (2014). Figure 5. Tenuifolin
Method i.g.
Cell Lines Kunming mice
Concentrations 200mg/kg
Incubation Time 30 min
Results As shown in Figure 5, when compared to control, 200mg/kg of OJB, TEN, and SNG had no significant effect on TNF-а level (p > 0.05).
Source Bioanalysis (2014). Figure 4. Tenuifolin
Method i.g.
Cell Lines Kunming mice
Concentrations 200mg/kg
Incubation Time 30 min
Results As shown in Figure 4, when compared to control, 200 mg/kg of OJB, TEN, or SNG could significantly reduce the gastric PGE2 level (p < 0.05), and the effects of OJB were greater than that of TEN (p< 0.05).
Cell Experiment
Cell lines PC12 cells
Preparation method The cells were inoculated into poly-L-lysine-coated 96-well culture plates at 5 × 103 cells/well and treated with different concentrations of tenuifolin and fallaxsaponin for 24 h and subsequently co-cultured with 25 μM prepared Aβ25–35 peptide for an additional 24 h.
Concentrations 10, 20 and 40 μg/L
Incubation time 24 h
Animal Experiment
Animal models dysmnesia mice
Formulation distilled water
Dosages 0.02, 0.04, 0.08 g/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 680.82
Formula C36H56O12
CAS Number 20183-47-5
Purity >98%
Solubility Methanol
Storage at -20°C

Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo.
Liu YM, et al. Pharmacol Biochem Behav. 2015 Jan;128:14-22. PMID: 25444865.

Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice.
Zhang H, et al. Phytomedicine. 2008 Aug;15(8):587-94. PMID: 18289838.

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Keywords: Tenuifolin supplier, AChR/AChE, inhibitors

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