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Sulfabenzamide

Cat. No. M5975
Sulfabenzamide Structure
Synonym:

Sultrin, N-Sulfanilylbenzamide

Size Price Availability Quantity
500mg USD 65  USD65 In stock
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Quality Control & Documentation
Biological Activity

Sulfabenzamide is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.

Chemical Information
Molecular Weight 276.31
Formula C13H12N2O3S
CAS Number 127-71-9
Form Solid
Solubility (25°C) 55 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bagheri F, et al. Mol Biol Rep. Stable overexpression of DNA fragmentation factor in T-47D cells: sensitization of breast cancer cells to apoptosis in response to acetazolamide and sulfabenzamide.

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Keywords: Sulfabenzamide, Sultrin, N-Sulfanilylbenzamide supplier, Autophagy, inhibitors, activators


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