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Stearic acid

Cat. No. M10316
Stearic acid Structure
Size Price Availability Quantity
5g USD 20  USD20 In stock
10g USD 30  USD30 In stock
50g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.

Chemical Information
Molecular Weight 284.48
Formula C18H36O2
CAS Number 57-11-4
Solubility (25°C) DMSO 100 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Valentina Spigoni, et al. Atherosclerosis. Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells

[2] Ming-Che Shen, et al. PLoS One. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice

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