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Ripasudil (K-115) dihydrate

Cat. No. M5933
Ripasudil (K-115) dihydrate Structure
Synonym:

Ripasudil

Size Price Availability Quantity
2mg USD 99  USD110 In stock
5mg USD 153  USD170 In stock
10mg USD 256.5  USD285 In stock
50mg USD 936  USD1040 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 395.88
Formula C15H23ClFN3O4S
CAS Number 887375-67-9
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma.
Yamamoto K, et al. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36. PMID: 25277230.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ripasudil (K-115) dihydrate, Ripasudil supplier, ROCK, inhibitors

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