Recombinant Murine IL-6 Protein is produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, and has a variety of biological functions. IL-6 is produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes. It promotes B cell differentiation and antibody production, and cooperates with IL-3 in megakaryocyte development and platelet production in the role of inducing acute liver protein expression, regulating bone metabolism. IL-6 transmits signals through the IL-6 receptor system, which consists of two chains, IL-6Rα and gp130. Mouse IL-6 has no effect on human cells.
Using mouse plasmacytoma cells T1126.96.36.199 cell proliferation assay to determine ED50, the value is 0.1-0.6 ng/mL.
Expression host is Human HEK293 cells
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Purity||≥95%, Endotoxin <2EU/ug|
|Storage||2-8°C, dry, sealed|
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