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Recombinant Murine IL-6 Protein

Cat. No. M10015
Recombinant Murine IL-6 Protein Structure
Size Price Availability Quantity
100ug USD 513  USD570 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin <2EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Murine IL-6 Protein is produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, and has a variety of biological functions. IL-6 is produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes. It promotes B cell differentiation and antibody production, and cooperates with IL-3 in megakaryocyte development and platelet production in the role of inducing acute liver protein expression, regulating bone metabolism. IL-6 transmits signals through the IL-6 receptor system, which consists of two chains, IL-6Rα and gp130. Mouse IL-6 has no effect on human cells. 

Using mouse plasmacytoma cells T1165.85.2.1 cell proliferation assay to determine ED50, the value is 0.1-0.6 ng/mL. 

Expression host is Human HEK293 cells

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin <2EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




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