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rac-Rotigotine (Hydrochloride)

Cat. No. M5914
rac-Rotigotine (Hydrochloride) Structure
Size Price Availability Quantity
10mg USD 72  USD80 In stock
50mg USD 184.5  USD205 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 351.93
Formula C19H26ClNOS
CAS Number 102120-99-0
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Influence of dose and route of administration on the enantioselective pharmacokinetics of TJ0711 hydrochloride in rats.
Sun S, et al. Chirality. 2015 Jan;27(1):53-7. PMID: 25315344.

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  Catalog
Abmole Inhibitor Catalog 2017




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