Free shipping on all orders over $ 500

Piperine

Cat. No. M5881
Piperine Structure
Synonym:

Bioperine; 1-Piperoylpiperidine

Size Price Availability Quantity
200mg USD 45  USD50 In stock
500mg USD 63  USD70 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 285.34
Formula C17H19NO3
CAS Number 94-62-2
Purity 99.89%
Solubility 47 mg/mL in DMSO
Storage at -20°C
References

Piperine inhibits the growth and motility of triple-negative breast cancer cells.
Greenshields AL, et al. Cancer Lett. 2015 Feb 1;357(1):129-40. PMID: 25444919.

Related P-gp Products
Elacridar hydrochloride

Elacridar hydrochloride is a p-gp inhibitor.

Valspodar

Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator.

Elacridar (GF120918)

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

Polyoxyethylene stearate

Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.

Sinapine-thiocyanate

Sinapine, an alkaloid derived from seeds of the cruciferous species, possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Piperine, Bioperine; 1-Piperoylpiperidine supplier, P-gp, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.