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Methionine

Cat. No. M1952
Methionine Structure
Synonym:

D-Methionine; MRX-1024

Size Price Availability Quantity
1g USD 49.5  USD55 In stock
2g USD 76.5  USD85 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities. When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 149.21
Formula C5H11NO2S
CAS Number 348-67-4
Purity >98%
Solubility Water ≥ 20 mg/mL
Storage 4°C, protect from light, dry, sealed
References

D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat.
Hinduja S, et al. Neurotox Res. 2015 Apr;27(3):199-204. PMID: 25488710.

Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitro studies using human plasma.
Sooriyaarachchi M, et al. Metallomics. 2014 Mar;6(3):532-41. PMID: 24337005.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Methionine, D-Methionine; MRX-1024 supplier, GABA Receptor, inhibitors

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