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Interferon alfa is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Interferon alfa requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function.
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Michele Baccarani, et al. Semin Hematol. Interferon-alfa for chronic myeloid leukemia
[3] G C Farrell. Hepatology. Therapy of hepatitis C: interferon alfa-n1 trials
[4] C D Williams, et al. Br J Hosp Med. Interferon alfa-2a
[5] R B Chambers, et al. J Am Osteopath Assoc. Interferon alfa-associated retinopathy
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