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Hexadecanedioic acid

Cat. No. M21461
Hexadecanedioic acid  Structure
Synonym:

Thapsic acid, Hexadecanedioate, Palmitic acid

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1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Hexadecanedioic acid is a common saturated fatty acid. Hexadecanedioic acid and Sepharose 4B are bound by covalent bond, which is more specific than dye resin and can be used to remove serum albumin (SA) from plasma.

Chemical Information
Molecular Weight 286.41
Formula C16H30O4
CAS Number 505-54-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alena A Semenova, et al. Biochimie. The stimulation of succinate-fueled respiration of rat liver mitochondria in state 4 by α,ω-hexadecanedioic acid without induction of proton conductivity of the inner membrane. Intrinsic uncoupling of the bc1 complex

[2] Rasa Santockyte, et al. Bioanalysis. LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions

[3] J Skorve, et al. J Lipid Res. On the mechanism of the hypolipidemic effect of sulfur-substituted hexadecanedioic acid (3-thiadicarboxylic acid) in normolipidemic rats

[4] J E Pettersen, et al. J Lipid Res. Subcellular localization of hexadecanedioic acid activation in human liver

[5] R Tzur, et al. Int J Obes. Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16)

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Keywords: Hexadecanedioic acid , Thapsic acid, Hexadecanedioate, Palmitic acid supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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