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HA 1100 hydrochloride

Cat. No. M6785
HA 1100 hydrochloride Structure
Synonym:

HA-1100 hydrochloride; HA 1100 hydrochloride; HA1100 hydrochloride

Size Price Availability
10mg USD 135  USD150 1-2 Weeks
50mg USD 405  USD450 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

HA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 343.83
Formula C14H17N3O3S.HCl
CAS Number 155558-32-0
Purity >98%
Solubility Water 6.88 mg/mL
Storage at -20°C
References

Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim and Cho. Acta Pharmacol Sinica. 2008;29: 113. PMID: 18158873.

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  Catalog
Abmole Inhibitor Catalog 2017




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