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Gadolinium chloride

Cat. No. M6741
Gadolinium chloride Structure
Size Price Availability Quantity
50mg USD 57  USD57 In stock
100mg USD 77  USD77 In stock
200mg USD 127  USD127 In stock
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Quality Control & Documentation
Biological Activity

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.

Chemical Information
Molecular Weight 263.61
Formula GdCl3
CAS Number 10138-52-0
Solubility (25°C) Water ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gulati P, et al. Naunyn Schmiedebergs Arch Pharmacol. Neuroprotective effect of gadolinium: a stretch-activated calcium channel blocker in mouse model of ischemia-reperfusion injury.

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