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Etomidate

Cat. No. M1893
Etomidate Structure
Synonym:

Amidate, R16659

Size Price Availability Quantity
50mg USD 108  USD120 In stock
100mg USD 198  USD220 In stock
200mg USD 252  USD280 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Etomidate (R16659) is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia and for sedation for short procedures such as reduction of dislocated joints, tracheal intubation and cardioversion. Etomidate selectively interacts with β2- and β3-subunit containing GABAA receptors. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage. Etomidate is highly protein bound in blood plasma and is metabolised by hepatic and plasma esterases to inactive products. It exhibits a bi-exponential decline. Etomidate is a useful agent for carefully conducted procedural sedation because it provides effective, brief, deep sedation with little hemodynamic compromise.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 244.29
Formula C14H16N2O2
CAS Number 33125-97-2
Purity >98%
Solubility DMSO 20 mg/mL
Ethanol 40 mg/mL
Storage at -20°C
References

Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABA(A) receptors.
Moody EJ, et al. Toxicol Lett. 1998 Nov 23;100-101:209-15. PMID: 10049144.

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Keywords: Etomidate, Amidate, R16659 supplier, GABA Receptor, inhibitors

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