Epinephrine bitartrate is an alpha- and beta-adrenergic receptor stimulator.
|Solubility (25°C)||67 mg/mL in DMSO|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Adrenergic Receptor Products|
Guanadrel is an orally active, spiroketal postganglionic adrenergic inhibitor containing a spirocyclic moiety in its structure, which may be used in studies related to hypertension.
Mabuterol is a selective, orally active beta-2 adrenergic receptor (β2-AR) agonist. Mabuterol inhibits PDGF-BB-induced cell proliferation, increased intracellular Ca2+, and Drp-1, cyclinD1, and PCNA protein expression, and enhances Mfn-2 expression. Can be used in studies of airway obstruction and chronic obstructive pulmonary disease (COPD).
DL-Norepinephrine hydrochloride is a synthetic phenylephrine that mimics the sympathomimetic effects of endogenous norepinephrine and is also a neurotransmitter targeting the adrenergic receptors α1 and β1, which have been shown to lower the subendocardial partial pressure of oxygen.
Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates.
Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol. Terbutaline can be used in asthma symptom research.
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