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Chlorhexidine diacetate

Cat. No. M19922
Chlorhexidine diacetate Structure
Synonym:

Hibitane diacetate

Size Price Availability Quantity
100mg USD 46  USD46 In stock
200mg USD 66  USD66 In stock
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Quality Control & Documentation
Biological Activity

Chlorhexidine diacetate is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Chemical Information
Molecular Weight 625.55
Formula C26H38Cl2N10O4
CAS Number 56-95-1
Solubility (25°C) DMSO 125.11 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] George J Holinga, et al. J Wound Care. In vitro antimicrobial effects of chlorhexidine diacetate versus chlorhexidine free base dressings

[2] Caroline Vieira Maluf, et al. J Appl Oral Sci. Evaluation of the physical and antifungal effects of chlorhexidine diacetate incorporated into polymethyl methacrylate

[3] Hctor A Lobato-Aguilar, et al. J Biomater Appl. Antibacterial properties and release kinetics of chlorhexidine diacetate from montmorillonite and palygorskite clays

[4] Morten S Opstrup, et al. Contact Dermatitis. Contact allergy to chlorhexidine in a tertiary dermatology clinic in Denmark

[5] I R Sanchez, et al. Vet Surg. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus

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